West Ham boss Rehanne Skinner makes four changes following her side's dramatic 4-3 defeat by Arsenal on Sunday.
Attacker Riko Ueki returns to the starting XI as do Katrina Gorry, Anouk Denton and Shelina Zadorsky.
Kirsty Smith, Camila Saez and Dagny Brynjarsdottir drop to the bench, while top scorer Viviane Asseyi is suspended after picking up her fifth booking of the season.
West Ham XI: Szemik, Denton, Nystrom, Tysiak, Zadorsky, Hanshaw, Siren, Gorry, Piubel, Ueki, Martinez.
Perhaps with this month's quadruple-header against Chelsea in mind, Gareth Taylor makes six changes to the Man City side who beat Tottenham Hotspur 2-1 on Sunday.
Naomi Layzell, Leila Ouahabi, Aoba Fujino, Vivianne Miedema, Laura Blindkilde Brown and Khadija Shaw all drop out, to be replaced by Jill Roord, Jess Park, Mary Fowler, Lily Murphy and Gracie Prior.
Lauren Wienroither makes her debut in defence after ing on loan from Arsenal in January.
Man City XI: Yamashita, Casparij, Wienroither, Aleixandri, Prior, Hasegawa, Roord, Park, Murphy, Fowler, Kerolin.
Welcomepublished at 18:30 Greenwich Mean Time 5 March
18:30 GMT 5 March
Good evening!
It's Wednesday, it's women's football. No, it's not the Champions League, or the League Cup, or postponed games being played, or the FA Cup. It's time for some midweek Women's Super League action.
We've got two games on the way tonight, with two of the top teams hoping to avoid dropping points.
Could their opponents pull off surprise results? West Ham nearly stunned Arsenal at the weekend and Leicester held Chelsea the last time the two met.
We're here to talk you through all of tonight's action, with live updates on both fixtures.
Let's kick off with the team news from our first game.